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Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple <i>Staphylococcus aureus</i> Genomes Identify Novel Antimicrobial Drug Targets

18 Apr 2009

Abstract excerpt

Mortality due to multidrug-resistant Staphylococcus aureus infection is predicted to surpass that of human immunodeficiency virus/AIDS in the United States. Despite the various treatment options for S. aureus infections, it remains a major hospital- and community-acquired opportunistic pathogen. With the emergence of multidrug-resistant S. aureus strains, there is an urgent need for the discovery of new...

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PMID: 19376871
DOI: 10.1128/jb.01743-08

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