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Article

Single-cell profiling reveals the origin of phenotypic variability in adipogenesis.

PloS one - 1 Jan 2009

Le Thuc T, Cheng Ji-Xin

Abstract excerpt

Phenotypic heterogeneity in a clonal cell population is a well-observed but poorly understood phenomenon. Here, a single-cell approach is employed to investigate non-mutative causes of phenotypic heterogeneity during the differentiation of 3T3-L1 cells into fat cells. Using coherent anti-Stokes Raman scattering microscopy and flow cytometry, adipogenic gene expression, insulin signaling, and glucose import are...

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Identifiers

PMID: 19357775
DOI: 10.1371/journal.pone.0005189
PMCID: PMC2663816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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