Article
Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection.
Molecular biology of the cell - 1 Jun 2009
Ishida Yoshihito, Yamamoto Akitsugu, Kitamura Akira, Lamandé Shireen R, Yoshimori Tamotsu, Bateman John F, Kubota Hiroshi, Nagata Kazuhiro
Abstract excerpt
Type I collagen is a major component of the extracellular matrix, and mutations in the collagen gene cause several matrix-associated diseases. These mutant procollagens are misfolded and often aggregated in the endoplasmic reticulum (ER). Although the misfolded procollagens are potentially toxic to the cell, little is known about how they are eliminated from the ER. Here, we show that procollagen that can...
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