Article
Diminished expression of S100A2, a putative tumour suppressor, is an independent predictive factor of neck node relapse in laryngeal squamous cell carcinoma.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale - 1 Feb 2009
Almadori Giovanni, Bussu Francesco, Galli Jacopo, Rigante Mario, Lauriola Libero, Michetti Fabrizio, Maggiano Nicola, Schafer Beat W, Heizmann Claus W, Ranelletti Franco O, Paludetti Gaetano
Abstract excerpt
PURPOSE: In primary squamous cell carcinoma of the larynx (LSCC), Ca(2+) binding S100A2 protein underexpression was already found to be associated with poor tumour differentiation and shorter overall survival. In the present work, the role of S100A2 protein expression in the prediction of regional metastasis-free survival (MFS) was investigated to guide neck management in LSCC. EXPERIMENTAL DESIGN: Specimens of...
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