Article
Low burden of a JAK2-V617F mutated clone in monoclonal haematopoiesis in a Japanese woman with Budd-Chiari syndrome.
International journal of hematology - 1 May 2009
Toyama Kohtaro, Karasawa Masamitsu, Yamane Arito, Koiso Hiromi, Yokohama Akihiko, Uchiumi Hideki, Saitoh Takayuki, Handa Hiroshi, Sato Ken, Takagi Hitoshi, Miyawaki Shuichi, Murakami Hirokazu, Nojima Yoshihisa, Tsukamoto Norifumi
Abstract excerpt
Approximately one-half of the cases of Budd-Chiari syndrome (BCS) are caused by bcr/abl negative chronic myeloproliferative disorders (CMPDs). Furthermore, a mutation in the Janus kinase protein (JAK2-V617F) is detected in half of the patients with BCS. However, whether the JAK2 mutation is the p...
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