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Article

Kaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processing

1 Jan 2009

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 (MTA, mRNA transcript accumulation) is a multifunctional regulator of the expression of viral lytic genes. KSHV ORF57 is expressed during viral lytic infection and is essential for virus production. Like its homologues in the herpesvirus family, ORF57 promotes the accumulation (stabilization) and export of viral intronless RNA transcripts by a mechanism which...

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PMID: 19273144
DOI: 10.2741/3322

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