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Article

Molecular analysis of activation-induced cytidine deaminase gene in immunoglobulin-E deficient patients.

Clinical & developmental immunology - 1 Jan 2008

Roa Sergio, Isidoro-Garcia Maria, Davila Ignacio, Laffond Elena, Lorente Felix, Gonzalez-Sarmiento Rogelio

Abstract excerpt

Understanding how class switch recombination (CSR) is regulated to produce immunoglobulin E (IgE) has become fundamental because of the dramatic increase in the prevalence of IgE-mediated hypersensitivity reactions. CSR requires the induction of the enzyme AICDA in B cells. Mutations in AICDA have been linked to Hyper-IgM syndrome (HIGM2), which shows absence of switching to IgE as well as to IgG and IgA....

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Source

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Identifiers

PMID: 19266080
DOI: 10.1155/2008/146715
PMCID: PMC2647753

Genes

AICDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular analysis of activation-induced cytidine deaminase gene in immunoglobulin-E deficient patients.PMID 19266080Read ↗

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