Article
Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations.
Pediatric nephrology (Berlin, Germany) - 1 Aug 2009
Bouba Ioanna, Siomou Ekaterini, Stefanidis Constantinos J, Emmanouilidou Anastasia, Galidi Anna, Hatzi Elissavet, Markoula Sofia, Mitsioni Andromachi, Siamopoulou Antigoni, Georgiou Ioannis
Abstract excerpt
Experimental studies have shown that homeobox genes are essential for the development of the kidney and urinary tract. Hoxa11/Hoxd11 double mutant mice demonstrate renal agenesis or hypoplasia. Since, to our knowledge, these genes have never been examined for alterations in humans with congenital...
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