Article
CTLA-4 +49A/G polymorphism is associated with Behçet's disease in a Tunisian population.
Tissue antigens - 1 Mar 2009
Ben Dhifallah I, Chelbi H, Braham A, Hamzaoui K, Houman M H
Abstract excerpt
The involvement of excessive T-helper cell functions in the pathogenesis of Behçet's disease (BD) has been reported. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays a role in T-cell downregulation. In this report, we investigated the possible association between BD patients and the CTLA-4 +49A/G polymorphism in Tunisian population. A total of 135 Tunisian BD patients and 151 healthy blood donors from the same...
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