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Article

MAO-A and COMT genotypes as possible regulators of perinatal serotonergic symptoms after in utero exposure to SSRIs.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 May 2009

Hilli Johanna, Heikkinen Tuija, Rontu Riikka, Lehtimäki Terho, Kishida Ikuko, Aklillu Eleni, Bertilsson Leif, Vahlberg Tero, Laine Kari

Abstract excerpt

Intrauterine exposure to SSRIs in late pregnancy can cause various serotonergic symptoms in the newborns. We associated the severity of these symptoms to neurotransmitter concentrations and genetic polymorphisms in the cytochrome P450, MAO-A and COMT enzymes. Altogether 20 children with prenatal exposure to citalopram or fluoxetine were genotyped. Infants with two high-activity alleles of the MAO-A gene had...

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Share to Catechol O-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monoamine Oxidase

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Share to Selective Serotonin Reuptake Inhibitors

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Source

Identifiers

PMID: 19223155
DOI: 10.1016/j.euroneuro.2009.01.006

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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