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Article

Drug-resistant molecular mechanism of CRF01_AE HIV-1 protease due to V82F mutation.

Journal of computer-aided molecular design - 1 May 2009

Liu Xiaoqing, Xiu Zhilong, Hao Ce

Abstract excerpt

Human immunodeficiency virus type 1 protease (HIV-1 PR) is one of the major targets of anti-AIDS drug discovery. The circulating recombinant form 01 A/E (CRF01_AE, abbreviated AE) subtype is one of the most common HIV-1 subtypes, which is infecting more humans and is expanding rapidly throughout the world. It is, therefore, necessary to develop inhibitors against subtype AE HIV-1 PR. In this work, we have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19219633
DOI: 10.1007/s10822-008-9256-x

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