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The Salmonella pathogenicity island 2-encoded type III secretion system is essential for the survival of Salmonella enterica serovar Typhimurium in free-living amoebae.

Applied and environmental microbiology - 1 Mar 2009

Bleasdale Benjamin, Lott Penelope J, Jagannathan Aparna, Stevens Mark P, Birtles Richard J, Wigley Paul

Abstract excerpt

Free-living amoebae represent a potential reservoir and predator of Salmonella enterica. Through the use of type III secretion system (T3SS) mutants and analysis of transcription of selected T3SS genes, we demonstrated that the Salmonella pathogenicity island 2 is highly induced during S. enterica serovar Typhimurium infection of Acanthamoeba polyphaga and is essential for survival within amoebae.

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Identifiers

PMID: 19168655
DOI: 10.1128/AEM.02033-08
PMCID: PMC2655480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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