Article
The heterogeneity of human antibody responses to vaccinia virus revealed through use of focused protein arrays.
Vaccine - 18 Feb 2009
Duke-Cohan Jonathan S, Wollenick Kristin, Witten Elizabeth A, Seaman Michael S, Baden Lindsey R, Dolin Raphael, Reinherz Ellis L
Abstract excerpt
The renewed interest in strategies to combat infectious agents with epidemic potential has led to a re-examination of vaccination protocols against smallpox. To help define which antigens elicit a human antibody response, we have targeted proteins known or predicted to be presented on the surface of the intracellular mature virion (IMV) or the extracellular enveloped virion (EEV). The predicted ectodomains were...
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