Article
Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives.
Blood - 21 May 2009
Lijfering Willem M, Brouwer Jan-Leendert P, Veeger Nic J G M, Bank Ivan, Coppens Michiel, Middeldorp Saskia, Hamulyák Karly, Prins Martin H, Büller Harry R, van der Meer Jan
Abstract excerpt
Thrombophilia screening is controversial. In a retrospective family cohort, where probands had thrombosis and a thrombophilic defect, 2479 relatives were tested for thrombophilia. In antithrombin-, protein C-, and protein S-deficient relatives, annual incidences of venous thrombosis were 1.77% (95% CI, 1.14-2.60), 1.52% (95% CI, 1.06-2.11), and 1.90% (95% CI, 1.32-2.64), respectively, at a median age of 29 years...
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