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Article

Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.

Blood - 16 Apr 2009

Ocio Enrique M, Maiso Patricia, Chen Xi, Garayoa Mercedes, Alvarez-Fernández Stela, San-Segundo Laura, Vilanova David, López-Corral Lucía, Montero Juan C, Hernández-Iglesias Teresa, de Alava Enrique, Galmarini Carlos, Avilés Pablo, Cuevas Carmen, San-Miguel Jesús F, Pandiella Atanasio

Abstract excerpt

Multiple myeloma (MM) remains incurable, and new drugs with novel mechanisms of action are still needed. In this report, we have analyzed the action of Zalypsis, an alkaloid analogous to certain natural marine compounds, in MM. Zalypsis turned out to be the most potent antimyeloma agent we have tested so far, with IC(50) values from picomolar to low nanomolar ranges. It also showed remarkable ex vivo potency in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19020308
DOI: 10.1182/blood-2008-09-177774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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