Article
Hunter syndrome in Jews in Israel: further evidence for prenatal selection favoring the Hunter allele.
Human genetics - 1 Mar 1991
Zlotogora J, Schaap T, Zeigler M, Bach G
Abstract excerpt
Among all the Jewish families with Hunter patients in Israel, 10 were Ashkenazi or Moroccan in origin. In those families, there was a paucity of new mutations. In addition, a significant deviation of the segregation ratio between the Hunter gene and the normal allele was demonstrated among the offspring of heterozygous mothers or siblings of affected children in these families. These results confirm and extend...
Topics
- Alleles
- Embryonic and Fetal Development
- Female
- Heterozygote
- Humans
- Israel
- Jews
- Male
- Mucopolysaccharidosis II
- Pedigree
- Selection, Genetic
- X Chromosome