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Article

Pharmacokinetics of tetrahydrobiopterin following oral loadings with three single dosages in patients with phenylketonuria.

Journal of inherited metabolic disease - 1 Feb 2009

Gramer G, Garbade S F, Blau N, Lindner M

Abstract excerpt

BACKGROUND: Tetrahydrobiopterin (BH(4)) loading has been performed for many years in patients detected by newborn screening for hyperphenylalaninaemia (HPA) to distinguish BH(4) cofactor synthesis or recycling defects from phenylalanine hydroxylase (PAH)-deficient HPA. Previous studies have shown that the pharmacokinetics of BH(4) shows high intra-individual and inter-individual variability. METHODS: Seventeen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19016342
DOI: 10.1007/s10545-008-0955-1

Genes

PAH

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Pharmacokinetics of tetrahydrobiopterin following oral loadings with three single dosages in patients with phenylketonuria.PMID 19016342Read ↗

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