Article
Inter-individual variation in expression: a missing link in biomarker biology?
Trends in biotechnology - 1 Jan 2009
Little Peter F R, Williams Rohan B H, Wilkins Marc R
Abstract excerpt
The past decade has seen an explosion of variation data demonstrating that diversity of both protein-coding sequences and of regulatory elements of protein-coding genes is common and of functional importance. In this article, we argue that genetic diversity can no longer be ignored in studies of human biology, even research projects without explicit genetic experimental design, and that this knowledge can, and...
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