FHM3 in familial hemiplegic migraine is more resistant to mutation than FHM1 and FHM2.

Abstract excerpt

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient hemiplegia. CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM. Here, a bioinformatics analysis was done to study the risk positions for mutation within the amino acid sequence of the three mentioned molecules. In this work, the author can identify many mutant prone positions...

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