Article
High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution.
PLoS genetics - 1 Nov 2008
Hasin Yehudit, Olender Tsviya, Khen Miriam, Gonzaga-Jauregui Claudia, Kim Philip M, Urban Alexander Eckehart, Snyder Michael, Gerstein Mark B, Lancet Doron, Korbel Jan O
Abstract excerpt
Olfactory receptors (ORs), which are involved in odorant recognition, form the largest mammalian protein superfamily. The genomic content of OR genes is considerably reduced in humans, as reflected by the relatively small repertoire size and the high fraction ( approximately 55%) of human pseudogenes. Since several recent low-resolution surveys suggested that OR genomic loci are frequently affected by copy-number...
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