Article
Non-nucleoside HIV-1 reverse transcriptase inhibitors di-halo-indolyl aryl sulfones achieve tight binding to drug-resistant mutants by targeting the enzyme-substrate complex.
Antiviral research - 1 Jan 2009
Samuele Alberta, Kataropoulou Alexandra, Viola Marco, Zanoli Samantha, La Regina Giuseppe, Piscitelli Francesco, Silvestri Romano, Maga Giovanni
Abstract excerpt
Indolyl aryl sulfone (IAS) non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have been previously shown to effectively inhibit wild-type (wt) and drug-resistant human immunodeficiency virus type 1 (HIV-1) replication. IASs proved to act through different mechanisms of action, depending on the nature and position of their chemical substituents. Here we describe selected novel IAS derivatives...
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