Article
Sensitivity and frequencies of dystrophin gene mutations in Thai DMD/BMD patients as detected by multiplex PCR.
Disease markers - 1 Jan 2008
Sura Thanyachai, Eu-ahsunthornwattana Jakris, Pingsuthiwong Sarinee, Busabaratana Manisa
Abstract excerpt
BACKGROUND: Duchenne muscular dystrophy (DMD), a lethal X-linked disease affecting 1 in 3500 male births, and its more benign variant, Becker muscular dystrophy (BMD), are caused by mutations in the dystrophin gene. Because of its large size, analysing the whole gene is impractical. Methods have been developed to detect the commonest mutations i.e. the deletions of the exons. Although these tests are highly...
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