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Article

Linking SNPs to CAG repeat length in Huntington's disease patients.

Nature methods - 1 Nov 2008

Liu Wanzhao, Kennington Lori A, Rosas H Diana, Hersch Steven, Cha Jang-Ho, Zamore Phillip D, Aronin Neil

Abstract excerpt

Allele-specific silencing using small interfering RNAs targeting heterozygous single-nucleotide polymorphisms (SNPs) is a promising therapy for human trinucleotide repeat diseases such as Huntington's disease. Linking SNP identities to the two HTT alleles, normal and disease-causing, is a prerequisite for allele-specific RNA interference. Here we describe a method, SNP linkage by circularization (SLiC), to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18931668
DOI: 10.1038/nmeth.1261
PMCID: PMC2587014

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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