Article
Variants in the ACVR1 gene are associated with AMH levels in women with polycystic ovary syndrome.
Human reproduction (Oxford, England) - 1 Jan 2009
Kevenaar Marlies E, Themmen Axel P N, van Kerkwijk Anke J, Valkenburg Olivier, Uitterlinden André G, de Jong Frank H, Laven Joop S E, Visser Jenny A
Abstract excerpt
BACKGROUND: Polycystic ovaries display an increased number of pre-antral and antral follicles compared with normal ovaries, suggesting that early and late follicle development are disturbed. The pathophysiology of this process is poorly understood. Since the transforming growth factor beta family members, anti-Müllerian hormone (AMH) and bone morphogenetic proteins (BMPs), inhibit FSH sensitivity, their...
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