Article
Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.
Molecular human reproduction - 1 Nov 2008
Singh Maneesh N, Stringfellow Helen F, Taylor Siân E, Ashton Kate M, Ahmad Mushfika, Abdo Khalil R, El-Agnaf Omar M A, Martin-Hirsch Pierre L, Martin Francis L
Abstract excerpt
Endometriosis is a debilitating disease in which apoptotic, genetic, immunological, angiogenic and environmental factors have been implicated. Endocrine-disrupting agents (e.g. dioxins) might be involved. Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1. Elevated expression of gamma-SYNUCLEIN (gamma-SYN) has been associated with hormone-related conditions....
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