Article
Apolipoprotein B gene mutations and fatty liver in Japanese hypobetalipoproteinemia.
Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2009
Katsuda Shoji, Kawashiri Masa-Aki, Inazu Akihiro, Tada Hayato, Tsuchida Masayuki, Kaneko Yoshibumi, Nozue Tsuyoshi, Nohara Atsushi, Okada Toshihide, Kobayashi Junji, Michishita Ichiro, Mabuchi Hiroshi, Yamagishi Masakazu
Abstract excerpt
BACKGROUND: Familial hypobetalipoproteinemia (FHBL) is a hereditary disorder characterized by decreased plasma concentrations of low-density lipoprotein cholesterol. The best-characterized causes of FHBL are apolipoprotein B (apoB) gene mutations, which produce truncated apoB proteins. Fatty liver is thought to be frequent in FHBL, owing to impaired secretion of very-low-density lipoprotein from the liver....
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