Article
The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development.
Proceedings of the National Academy of Sciences of the United States of America - 23 Sept 2008
Bach Liên, Michaelson Louise V, Haslam Richard, Bellec Yannick, Gissot Lionel, Marion Jessica, Da Costa Marco, Boutin Jean-Pierre, Miquel Martine, Tellier Frédérique, Domergue Frederic, Markham Jennifer E, Beaudoin Frederic, Napier Johnathan A, Faure Jean-Denis
Abstract excerpt
Very-long-chain fatty acids (VLCFAs) are synthesized as acyl-CoAs by the endoplasmic reticulum-localized elongase multiprotein complex. Two Arabidopsis genes are putative homologues of the recently identified yeast 3-hydroxy-acyl-CoA dehydratase (PHS1), the third enzyme of the elongase complex. We showed that Arabidopsis PASTICCINO2 (PAS2) was able to restore phs1 cytokinesis defects and sphingolipid long chain...
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