Article
Comparative Omics Reveals Unanticipated Metabolic Rearrangements in a High-Oil Mutant of Plastid Acetyl-CoA Carboxylase.
Journal of proteome research - 6 Jun 2025
Kataya Amr, Nascimento Jose Roberto S, Xu Chunhui, Garneau Matthew G, Koley Somnath, Kimberlin Athen, Mukherjee Thiya, Mooney Brian P, Xu Dong, Bates Philip D, Allen Doug K, Koo Abraham J, Thelen Jay J
Abstract excerpt
Heteromeric acetyl-CoA carboxylase (ACCase) catalyzes the ATP-dependent carboxylation of acetyl-CoA to produce malonyl-CoA, which is the committed step for de novo fatty acid synthesis. In plants, ACCase activity is controlled at multiple levels, including negative regulation by biotin attachment domain-containing (BADC) proteins, of which the badc1/3 double mutant leads to increased seed triacylglycerol...
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