Article
High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk nuclear test site.
Journal of radiation research - 1 Sept 2008
Zharlyganova Dinara, Harada Hironori, Harada Yuka, Shinkarev Sergey, Zhumadilov Zhaxybay, Zhunusova Aigul, Tchaizhunusova Naylya J, Apsalikov Kazbek N, Kemaikin Vadim, Zhumadilov Kassym, Kawano Noriyuki, Kimura Akiro, Hoshi Masaharu
Abstract excerpt
It is known that bone marrow is a sensitive organ to ionizing radiation, and many patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) have been diagnosed in radiation-treated cases and atomic bomb survivors in Hiroshima and Nagasaki. The AML1/RUNX1 gene has been known to be frequently mutated in MDS/AML patients among atomic bomb survivors and radiation therapy-related MDS/AML patients....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.