Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Expression and function of non-muscle myosin-IIA in Fechtner syndrome].

Zhongguo shi yan xue ye xue za zhi - 1 Aug 2008

Yang Hai-Yan, Wang Zhao-Yue, Cao Li-Juan, Zhao Xiao-Juan, Bai Xia, Ruan Chang-Geng

Abstract excerpt

The study was purposed to investigate the expression and function of non-muscle myosin heavy chain-IIA (NMMHC-IIA) in Fechtner syndrome in order to explore the pathologic changes of kindy disease and the mechanism of granulocyte inclusion body formation. NMMHC-IIA levels in granulocytes were analyzed by Western-blot, the expressions of NMMHC-IIA, IIB in HEK-293 cells were detected by RT-PCR and were analyzed by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Platelet Disorders
Share to Cell Line
Share to Granulocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inclusion Bodies

Share to Kidney

Share to Mutation

Share to Syndrome

Share to Thrombocytopenia

Source

Identifiers

PMID: 18718080

Genes

MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

[Expression and function of non-muscle myosin-IIA in Fechtner syndrome].PMID 18718080Read ↗

[May-Hegglin anomaly: past and present--novel diagnostic test and new concept of the disease].Semantic proximity Read ↗

Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders.Semantic proximity Read ↗

[Fechtner syndrome, a nonmuscle myosin heavy chain 9 gene mutation related disease: a case report and literature review].Semantic proximity Read ↗

Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains.Semantic proximity Read ↗

Analysis of clinical manifestations, mutant gene and encoded protein in two Chinese MYH9-related disease families.Semantic proximity Read ↗

Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations.Semantic proximity Read ↗

Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age.Semantic proximity Read ↗

Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function.Semantic proximity Read ↗

Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders.Semantic proximity Read ↗

Successful immunostaining demonstrates abnormal intracytoplasmic MYH9 protein (NMMHC-IIA) in neutrophils of a dog with May-Hegglin anomaly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.