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Article

The Transcription Factor Gene<i>FOXC1</i>Exhibits a Limited Role in Primary Congenital Glaucoma

1 Jan 2009

Abstract excerpt

PURPOSE: Primary congenital glaucoma (PCG) is an autosomal recessive disorder that has been linked to CYP1B1 mutations. This study was conducted to explore the role of FOXC1, which is involved in anterior segment dysgenesis, in PCG. METHODS: An earlier screening for CYP1B1 in a clinically well-characterized PCG cohort (n = 301) revealed cases that were either homozygous (n = 73), compound heterozygous (n = 18),...

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PMID: 18708620
DOI: 10.1167/iovs.08-2253

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