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Targeting Epigenetic Mechanisms: Potential of Natural Products in Cancer Chemoprevention

14 Aug 2008

Abstract excerpt

The term epigenetics is defined as heritable changes in gene expression patterns that occur without changes in DNA sequence. Epigenetic changes according to this definition are achieved by methylation of cytosine bases in the DNA and by histone modifications, such as acetylation, methylation or phosphorylation. These modifications play an important role in regulating gene expression and the existence of an...

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PMID: 18704881
DOI: 10.1055/s-2008-1081347

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