Article
Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
Japanese journal of clinical oncology - 1 Sept 2008
Mahajan Rajeev, El-Omar Emad M, Lissowska Jolanta, Grillo Paolo, Rabkin Charles S, Baccarelli Andrea, Yeager Meredith, Sobin Leslie H, Zatonski Witold, Channock Stephen J, Chow Wong-Ho, Hou Lifang
Abstract excerpt
Host immune responses are known determinants of gastric cancer susceptibility. We previously reported an increased gastric cancer risk associated with common variants of several T helper type 1 (Th1) cytokine genes in a population-based case-control study in Warsaw, Poland. In the present study, we augmented our investigation to include additional Th1 genes as well as key genes in the Th2 and Th3 pathways....
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