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Article

Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome.

Journal of cardiovascular electrophysiology - 1 Dec 2008

Moss Arthur J, Zareba Wojciech, Schwarz Karl Q, Rosero Spencer, McNitt Scott, Robinson Jennifer L

Abstract excerpt

INTRODUCTION: One form of the hereditary long-QT syndrome, LQT3-Delta KPQ, is associated with sustained inward sodium current during membrane depolarization. Ranolazine reduces late sodium channel current, and we hypothesized that ranolazine would have beneficial effects on electrical and mechanical cardiac function in LQT3 patients with the SCN5A-DeltaKPQ mutation. METHODS: We assessed the effects of 8-hour...

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Identifiers

PMID: 18662191
DOI: 10.1111/j.1540-8167.2008.01246.x
PMCID: PMC2614458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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