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Identification and characterization of Shiga toxin type 2 variants in Escherichia coli isolates from animals, food, and humans.

Applied and environmental microbiology - 1 Sept 2008

Zheng Jie, Cui Shenghui, Teel Louise D, Zhao Shaohua, Singh Ruby, O'Brien Alison D, Meng Jianghong

Abstract excerpt

There is considerable heterogeneity among the Shiga toxin type 2 (Stx2) toxins elaborated by Shiga toxin-producing Escherichia coli (STEC). One such Stx2 variant, the Stx2d mucus-activatable toxin (Stx2dact), is rendered more toxic by the action of elastase present in intestinal mucus, which cleaves the last two amino acids of the A2 portion of the toxin A subunit. We screened 153 STEC isolates from food,...

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Identifiers

PMID: 18658282
DOI: 10.1128/AEM.00503-08
PMCID: PMC2547040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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