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Article

Identification and characterization of new variants of three associated SNPs and a microsatellite in the TSH receptor gene which are useful for genetic studies.

Molecular and cellular probes - 1 Jan 2000

Esperante Sebastián A, Rivolta Carina M, Caputo Mariela, González-Sarmiento Rogelio, Targovnik Héctor M

Abstract excerpt

The purpose of the present work was to characterize g.IVS5-69C>T, g.IVS6+13C>T and c.561C>T SNPs and the [CT](n) microsatellite in the TSHR gene for genetic analysis. Exons 6 and 7 of the TSHR gene, including the flanking intronic sequences, were screened for the presence of g.IVS5-69C>T, g.IVS6+13C>T and c.561C>T SNPs by SSCP. We found genetic association between the three SNPs and a total of three different...

Topics

Base Sequence
Exons
Haplotypes
Humans
Microsatellite Repeats
Molecular Sequence Data
Polymorphism, Single Nucleotide
Receptors, Thyrotropin
Sequence Analysis, DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18652889
DOI: 10.1016/j.mcp.2008.06.003

Genes

TSHR
CAT

Variants

Provenance

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