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Article

Good response to IL-1beta blockade by anakinra in a 23-year-old CINCA/NOMID patient without mutations in the CIAS1 gene. Cytokine profiles and functional studies.

Scandinavian journal of rheumatology - 1 Jan 2000

Hedrich C M, Fiebig B, Sallmann S, Bruck N, Hahn G, Roesler J, Roesen-Wolff A, Heubner G, Gahr M

Abstract excerpt

Chronic infantile neurological cutaneous and articular (CINCA) syndrome is an autoinflammatory disease, defined by the triad of urticarial rash, neurological manifestations, and arthropathy, accompanied by recurrent fevers and systemic inflammation. Increasing neurological deficits result from as...

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Identifiers

PMID: 18609262
DOI: 10.1080/03009740801978889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18609262-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Good response to IL-1beta blockade by anakinra in a 23-year-old CINCA/NOMID patient without mutations in the CIAS1 gene. Cytokine profiles and functional studies.PMID 18609262Read ↗

The clinical course of a child with CINCA/NOMID syndrome improved during and after treatment with thalidomide.Semantic proximity Read ↗

New CIAS1 mutation and anakinra efficacy in overlapping of Muckle-Wells and familial cold autoinflammatory syndromes.Semantic proximity Read ↗

Two German CINCA (NOMID) patients with different clinical severity and response to anti-inflammatory treatment.Semantic proximity Read ↗

Current status of understanding the pathogenesis and management of patients with NOMID/CINCA.Semantic proximity Read ↗

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.Semantic proximity Read ↗

[Significant effect of IL-1 receptor antagonist treatment in two patients who had CINCA syndrome with constant symptoms for 13 years].Semantic proximity Read ↗

Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra.Semantic proximity Read ↗

CINCA Syndrome.Semantic proximity Read ↗

Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes.Semantic proximity Read ↗

Neonatal treatment of CINCA syndrome.Semantic proximity Read ↗

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition.Semantic proximity Read ↗

Enhanced interleukin-1beta and interleukin-18 release in a patient with chronic infantile neurologic, cutaneous, articular syndrome.Semantic proximity Read ↗

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