Article
Human papillomavirus infection in oral verrucous carcinoma: genotyping analysis and inverse correlation with p53 expression.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2008
Fujita Shuichi, Senba Masachika, Kumatori Atsushi, Hayashi Tomayoshi, Ikeda Tohru, Toriyama Kan
Abstract excerpt
OBJECTIVE: Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma, occurring mostly in oral mucosa. To clarify the role of human papillomavirus (HPV) in VC tumorigenesis, we investigated localization and genotypes of HPV and p53 expression in oral VC. METHODS: We studied paraffin-embedded specimens of 23 VCs and 10 control non-neoplastic lesions in oral mucosa. To investigate HPV infection, HPV...
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