Article
CACNA1A mutation linking hemiplegic migraine and alternating hemiplegia of childhood.
Cephalalgia : an international journal of headache - 1 Aug 2008
de Vries B, Stam A H, Beker F, van den Maagdenberg A M J M, Vanmolkot K R J, Laan Laem, Ginjaar I B, Frants R R, Lauffer H, Haan J, Haas J P, Terwindt G M, Ferrari M D
Abstract excerpt
Familial hemiplegic migraine (FHM) and alternating hemiplegia of childhood (AHC) are severe neurological disorders that share clinical features. Therefore, FHM genes are candidates for AHC. We performed mutation analysis in the CACNA1A gene in a monozygotic twin pair with clinical features overlapping with both AHC and FHM and identified a novel de novo CACNA1A mutation. We provide the first evidence that a...
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