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Article

MELAS mitochondrial DNA mutation A3243G reduces glutamate transport in cybrids cell lines.

Experimental neurology - 1 Jul 2008

DiFrancesco Jacopo C, Cooper J Mark, Lam Amanda, Hart Paul E, Tremolizzo Lucio, Ferrarese Carlo, Schapira Antony H

Abstract excerpt

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) is commonly associated with the A3243G mitochondrial DNA (mtDNA) mutation encoding the transfer RNA of leucine (UUR) (tRNA (Leu(UUR))). The pathogenetic mechanisms of this mutation are not completely understo...

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Identifiers

PMID: 18455161
DOI: 10.1016/j.expneurol.2008.03.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18455161-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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