Article
Precision-mapping and statistical validation of quantitative trait loci by machine learning.
BMC genetics - 2 May 2008
Bedo Justin, Wenzl Peter, Kowalczyk Adam, Kilian Andrzej
Abstract excerpt
BACKGROUND: We introduce a QTL-mapping algorithm based on Statistical Machine Learning (SML) that is conceptually quite different to existing methods as there is a strong focus on generalisation ability. Our approach combines ridge regression, recursive feature elimination, and estimation of generalisation performance and marker effects using bootstrap resampling. Model performance and marker effects are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.