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Article

Retrospective on reverse genetics in mice around the world and in Japan.

Development, growth & differentiation - 1 Jun 2008

Aizawa Shinichi

Abstract excerpt

The 2007 Nobel Prize for Physiology or Medicine was awarded to Mario R. Capecchi, Martin J. Evans and Oliver Smithies for their contribution in generating mutant mice by gene targeting in embryonic stem (ES) cells. Although there are many experimental animals, it is yet only in mouse that one can genetically examine functions of genes at will. It was merely a dream in the early 1980s that genetic studies with...

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PMID: 18430168
DOI: 10.1111/j.1440-169X.2008.01004.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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