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Article

Autophagy: An overlooked mechanism of HIV-1 pathogenesis and NeuroAIDS?

24 Apr 2008

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) establishes a persistent infection characterized by progressive depletion of CD4(+) lymphocytes and immunosuppression. Although extensive research has examined the importance of apoptosis as a cause of cell death associated with HIV-1 infection, the role of autophagy has been largely ignored. Our laboratory has examined the autophagic process in HIV-1-infected cells....

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PMID: 18424919
DOI: 10.4161/auto.6105

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