Article
Contribution of CYP1B1 mutations and founder effect to primary congenital glaucoma in Mexico.
Journal of glaucoma - 1 Jan 2000
Zenteno Juan Carlos, Hernandez-Merino Elena, Mejia-Lopez Herlinda, Matías-Florentino Margarita, Michel Norma, Elizondo-Olascoaga Celia, Korder-Ortega Vincent, Casab-Rueda Homero, Garcia-Ortiz Jose Elias
Abstract excerpt
PURPOSE: The frequency of primary congenital glaucoma (PCG)-causing CYP1B1 mutations varies importantly among distinct populations, ranging from 20% in Indonesians and Japanese to about 100% among the Saudi Arabians and Slovakian Gypsies. Thus, the molecular characterization of large groups of PCG from different ethnic backgrounds is important to establish the actual CYP1B1 contribution in specific populations....
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