Article
Contributions of spermatozoa to embryogenesis: assays to evaluate their genetic and epigenetic fitness.
Reproductive biomedicine online - 1 Apr 2008
Carrell Douglas T
Abstract excerpt
During fertilization, spermatozoa contribute genetic and epigenetic factors that affect early embryogenesis. Genetic factors include a haploid genome with intact coding regions and regulatory regions for essential genes. The DNA must contain the proper copy number of essential genes, and cannot have increased single- or double- stranded DNA breaks. Epigenetic factors include a functional centrosome, proper...
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