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Article

Single-step scalable-throughput molecular screening for Huntington disease.

Clinical chemistry - 1 Jun 2008

Teo Clara R L, Wang Wen, Yang Law Hai, Lee Caroline G, Chong Samuel S

Abstract excerpt

BACKGROUND: Huntington disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by an unstable expansion of the CAG trinucleotide repeat in exon 1 of the HTT (huntingtin) gene and typically has an adult onset. Molecular diagnosis and screening for HD currently involve separate amplification and detection steps. METHODS: We evaluated a novel, rapid microplate-based screening method for HD that...

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Source

Identifiers

PMID: 18403567
DOI: 10.1373/clinchem.2007.096503

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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