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Article

Monozygotic twins discordant for the major signs of McCune-Albright syndrome.

American journal of medical genetics - 1 Nov 1991

Endo M, Yamada Y, Matsuura N, Niikawa N

Abstract excerpt

We describe a girl, one of monozygotic (MZ) twins, with endocrine dysfunction with precocious puberty, café-au-lait nevi and polyostotic fibrous dysplasia (PFD), McCune-Albright syndrome (MAS). After treatment with cyproterone acetate for 7 years the precocious puberty and excess growth improved but the bone-age still remain advanced. The co-twin had an advanced bone-age and a small café-au-lait spot, but showed...

Topics

Child, Preschool
Cyproterone
Cyproterone Acetate
Diseases in Twins
Estradiol
Female
Fibrous Dysplasia, Polyostotic
Follicle Stimulating Hormone
Genetic Markers
Gonadotropin-Releasing Hormone
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Luteinizing Hormone

Mutation

Puberty, Precocious

Radionuclide Imaging

Twins, Monozygotic

Source

Identifiers

PMID: 1838461
DOI: 10.1002/ajmg.1320410217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1838461-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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