Article
Microevolution of Dengue viruses circulating among primary school children in Kamphaeng Phet, Thailand.
Journal of virology - 1 Jun 2008
Jarman Richard G, Holmes Edward C, Rodpradit Prinyada, Klungthong Chonticha, Gibbons Robert V, Nisalak Ananda, Rothman Alan L, Libraty Daniel H, Ennis Francis A, Mammen Mammen P, Endy Timothy P
Abstract excerpt
To determine the extent and structure of genetic variation in dengue viruses (DENV) on a restricted spatial and temporal scale, we sequenced the E (envelope) genes of DENV-1, -2, and -3 isolates collected in 2001 from children enrolled in a prospective school-based study in Kamphaeng Phet, Thailand, and diagnosed with dengue disease. Our analysis revealed substantial viral genetic variation in both time and...
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