Mutational load distribution analysis yields metrics reflecting genetic instability during pancreatic carcinogenesis.

doi:10.1073/pnas.0708250105

Article

Mutational load distribution analysis yields metrics reflecting genetic instability during pancreatic carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008

Tarafa Gemma, Tuck David, Ladner Daniela, Topazian Mark, Brand Randall, Deters Carolyn, Moreno Victor, Capella Gabriel, Lynch Henry, Lizardi Paul, Costa Jose

Abstract excerpt

Considering carcinogenesis as a microevolutionary process, best described in the context of metapopulation dynamics, provides the basis for theoretical and empirical studies that indicate it is possible to estimate the relative contribution of genetic instability and selection to the process of t...

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