Article
Bone marrow multipotent mesenchymal stromal cells do not reduce fibrosis or improve function in a rat model of severe chronic liver injury.
Stem cells (Dayton, Ohio) - 1 May 2008
Carvalho Adriana B, Quintanilha Luiz Fernando, Dias Juliana V, Paredes Bruno D, Mannheimer Elida G, Carvalho Felipe G, Asensi Karina D, Gutfilen Bianca, Fonseca Lea Mirian B, Resende Celia Maria C, Rezende Guilherme F M, Takiya Christina M, de Carvalho Antonio Carlos Campos, Goldenberg Regina C S
Abstract excerpt
The objective of our study was to evaluate the therapeutic potential of bone marrow mesenchymal stromal cells (MSC) in a rat model of severe chronic liver injury. Fourteen female Wistar rats were fed exclusively an alcoholic liquid diet and received intraperitoneal injections of carbon tetrachloride every other day during 15 weeks. After this period, eight animals (MSC group) had 1 x 10(7) cells injected into the...
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